Ruination:

Kalista seeks to change that. When her young and narcissistic uncle, Viego, becomes king, she vows to temper his destructive instincts, as his loyal confidant, advisor, and military general. But her plans are thwarted when an assassin's poisoned blade strikes Viego's wife, Isolde, afflicting her with a malady for which there is no cure. As Isolde's condition worsens, Viego descends into madness and grief, threatening to drag Camavor down with him. Kalista makes a desperate gambit to save the kingdom: she searches for the long lost Blessed Isles, rumored to hold the queen's salvation, if only Kalista can find them.

Ambessa Medarda: Warrior, general, mother. She is a woman to be feared, and the Medardas are unrivaled in their pursuit of glory. She has led conquests and armies. She has slain legendary beasts. She has made grave sacrifices in her ascent up the ranks. And for this she was rewarded: She entered the realm of death and was granted a vision of herself upon the throne of the vast Noxian empire. But before she can lead her empire, she must become head of her own clan. Yet the title is contested by her cousin and former confidante, Ta'Fik. He knows the bloody sins of Ambessa's past. And he knows he cannot allow her to rise....