Hard-hitting, page-turning and celebratory of friendship in unlikely circumstances, Joyce Carol Oates' sure touch with small town life hits home in her first young adult novel.Matt Donaghy is the class joker, and Ursula Riggs is the misfit loner. Neither knows the other. But when Matt is suddenly arrested on a charge of threatening to blow up the school and massacre the students, Ursula is the only one who sees through the hysteria and hypocrisy, and corroborates Matt's story.The case is dropped, but Matt's old friends avoid him, and his teachers treat him with kid gloves. Even Ursula, apparently his only friend during the crisis, can't meet his eye. But Ursula can't remain aloof when she catches Matt contemplating suicide – and a strange friendship is born.

In this harrowing story based on authentic historical documents, we follow the career of Dr. Silas Weir, “Father of Gyno-Psychiatry,” as he ascends from professional anonymity to national renown. Humiliated by a procedure gone terribly wrong, Weir is forced to take a position at the New Jersey Asylum for Female Lunatics, where he reigns. There, he is allowed to continue his practice, unchecked for decades, making a name for himself by focusing on women who have been neglected by the state―women he subjects to the most grotesque modes of experimentation. As he begins to establish himself as a pioneer of nineteenth-century surgery, Weir’s ambition is fueled by his obsessive fascination with a young Irish indentured servant named Brigit, who becomes not only Weir’s primary experimental subject, but also the agent of his destruction.